Exhaled Nitric Oxide in COPD

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Exhaled nitric oxide and COPD.

We were interested to read the paper by LEHTIMÄKI et al. [1] recently published in the European Respiratory Journal, in which those authors reported that ‘‘high pre-treatment levels of J9aw,NO [bronchial nitric oxide flux] are related to symptom relief and improvement of airway obstruction’’ when inhaled fluticasone is given to patients with chronic obstructive pulmonary disease (COPD). Their d...

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Exhaled nitric oxide in COPD: glancing through a smoke screen.

There is worldwide increasing awareness of the human and socioeconomic impact of chronic obstructive pulmonary disease (COPD) which is a major cause of morbidity and mortality. Even though its pathogenesis in industrialised countries is linked to a well known cause—namely, tobacco smoking—it is not envisaged that this knowledge will lead to breakthroughs in the prevention of this disease during...

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Repeatability of exhaled nitric oxide measurements in patients with COPD

The assessment of the presence of eosinophilic airway inflammation may help in predicting the steroid response in subjects with respiratory symptoms. Unlike patients with asthma, only a subset of patients with chronic obstructive pulmonary disease (COPD) benefits from steroid treatment. Fractional exhaled nitric oxide (FENO) is a useful surrogate marker for eosinophilic airway inflammation, but...

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Exhaled nitric oxide from lung periphery is increased in COPD.

Single constant flow exhaled nitric oxide (eNO) cannot distinguish between the sources of NO. The present study measured eNO at multiple expired flows (MEFeNO) to partition NO into alveolar (Calv,NO) and bronchial (Jaw,NO) fractions to investigate peripheral lung contribution to eNO in chronic obstructive lung disease (COPD). MEFeNO were made in 81 subjects including 18 nonsmokers, 16 smokers a...

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Exhaled nitric oxide monitoring in COPD using a portable analyzer.

BACKGROUND The exhaled nitric oxide (FeNO) is a non-invasive marker of airway inflammation in asthma. A very recent statement has suggested FeNO as potential outcome in chronic obstructive pulmonary disease (COPD). Recently, a new hand-held FeNO analyzer (NIOX MINO) has been developed. PATIENTS AND METHODS We have evaluated the NIOX MINO in COPD patients and monitored FeNO levels during 1-yea...

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ژورنال

عنوان ژورنال: Current Respiratory Medicine Reviews

سال: 2019

ISSN: 1573-398X

DOI: 10.2174/1573398x14666181025150537